Matthew Jorgenson Ph.D.
Research Assistant Professor
Ph.D.: The University of Iowa
Lab: Biomed I, Room 511
Phone: (501) 526-6805


Research Description
All bacteria have a shape and, for the most part, this shape is determined by a rigid casing known as the peptidoglycan cell wall. My research focuses on understanding how cells produce and maintain the peptidoglycan layer. This includes studying cytoskeletal proteins (i.e. FtsZ and MreB), peptidoglycan modifying enzymes, and other morphological mechanisms.


Jorgenson MA, Young KD. 2016. Interrupting Biosynthesis of O Antigen or the Lipopolysaccharide Core Produces Morphological Defects in Escherichia coli by Sequestering Undecaprenyl Phosphate. J Bacteriol 198:3070-3079.

Jorgenson MA, Kannan S, Laubacher ME, Young KD. 2016. Dead-end intermediates in the enterobacterial common antigen pathway induce morphological defects in Escherichia coli by competing for undecaprenyl phosphate. Molecular Microbiology 100:1-14

Yahashiri A, Jorgenson MA, Weiss DS. 2015. Bacterial SPOR domain are recruited to septal peptidoglycan by binding to glycan strands that lack stem peptides. Proceedings of the National Academy of Sciences USA 112:11347-11352.

Jorgenson MA, Chen Y, Yahashiri A, Popham DL, Weiss DS. 2014. The bacterial septal ring protein RlpA is a lytic transglycosylase that contributes to rod shape and daughter cell separation in Pseudomonas aeruginosa. Molecular Microbiology 93: 113-128.

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