Post Doctoral Fellow

Ph.D. : University of Calcutta, India.
Mentor:  Roger Pechous
Lab: Biomed I Room B529.
Phone: (501) 686 5317
Email:

 

Research Description

My Ph.D. research at Bose Institute, University of Calcutta, India, focused on signal transduction of Mycobacterium tuberculosis. I joined Dr. Roger Pechous as a post-doctoral fellow in May, 2017. In the Pechous lab, I study the pathogenesis and progression of pneumonic plague. Yersinia pestis, when transmitted through aerosols can cause primary pneumonic plague. The disease is characterized by an almost asymptomatic pre-inflammatory phase followed by the rapid onset of a pro-inflammatory phase which can be fatal without immediate treatment. We are trying to find answers to fundamental questions like,

  •   What are the early host-pathogen interactions that dictate the pre-inflammatory phase?
  •   How does the switch to the pro-inflammatory phase occur?

I am developing an ex vivo human lung tissue platform to study early interactions of the bug with the human lung environment. At the same time, I am exploring the differences in pathogenesis of Y. pestis and Y. pseudotuberculosis because the latter fails to establish a fatal infection in the human lung.

Publications:

Banerjee S K, Kumar M, Alokam R, Sharma A K, Chatterjee A, Kumar R, Sahu S K, Jana K, Singh R, Yogeeswari P, Sriram D, Basu J and Kundu M, Targeting multiple response regulators of Mycobacterium tuberculosis augments the host immune response to infection. Sci. Rep. 6, 25851, doi: 10.1038/srep25851, 2016.

Sahu S K, Kumar M, Chakraborty S, Banerjee SK, Kumar R, Gupta P, et al. MicroRNA 26a (miR-26a)/KLF4 and CREB-C/EBPβ regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection. PLoS Pathog 13(5): e1006410. https://doi.org/10.1371/journal.ppat.1006410, 2017.

Gupta S, Banerjee S K, Chaterjee A, Sharma A, Kundu M & Basu J, The essential protein SepF of mycobacteria interacts with FtsZ and MurG to regulate cell growth and division. Microbiology, 161: 1627-1638, 2015.

Sanyal S, Banerjee S K, Banerjee R, Mukhopadhyay J & Kundu M, Polyphosphate kinase 1, a central node in the stress response network of Mycobacterium tuberculosis connects the two-component systems MprAB and SenX3–RegX3 and the extracytoplasmic function sigma factor, sigma E. Microbiology, 159: 2074-2086, 2013.