Nalini S. Bora, Ph.D.

Bernice Y. Jones Professor of Ophthalmology Professor of Microbiology and Immunology 

Research Interest:  Innate & Autoimmunity in ocular diseases (Age-related macular  degeneration, uveitis, ocular tumors etc.)
Ph.D., All India Institute of Medical Sciences, New Delhi, India
Postdoctoral:  Washington University School of Medicine, St. Louis, MO
Phone: (501) 686-8293 
Fax:     
(501) 686-8316

E-mail

Research Description

My research is focused upon the understanding of biochemical, immunological and molecular mechanisms of various ocular disease such uveitis, age-related macular degeneration (AMD), keratitis and ocular tumors.  My laboratory is first to demonstrate the importance of innate immune response (i.e. Complement System) in the protection of normal ocular tissues against infection as well as in systemic tolerance after the introduction of an antigen in the anterior segment of the eye.  For the first time my laboratory provided an important link between innate immunity and ocular auto-immunity using an animal model of idiopathic anterior uveitis.  Furthermore, we were first to demonstrate that the activation of complement system is crucial for the development of choroidal neo-vascularization (CNV) in wet-type AMD and keratitis.  Currently, my laboratory is investigating the role of innate immune response in the survival and metastasis of ocular tumors.

References

Bora, N.S. Jha, P. and Bora P.S. The role of complement in ocular pathology (Review Article). Seminars in Immunopathology, 30: 85-95, 2008.

Matta, B., Jha, P., Bora P.S. and Bora, N.S. Tolerance to Melanin Associated Antigen in Auto-immune Uveitis is Mediated by CD4+CD25+ T Regulatory Cells. American Journal of Pathology, 173: 1440-1454, 2008.

Jha, P., Bora P.S. and Bora, N.S. The role of complement system in ocular diseases including uveitis and macular degeneration (Review Article). Molecular Immunology, 44, 3901 – 3908, 2007.

Bora, N.S., Kaliappan, S., Jha, P., Xu, Q., Sivasankar, B., Harris, C.L., Morgan, B.P. and Bora, P.S. CD59, a Complement Regulatory Protein, Controls Choroidal Neovascularization in Wet-type Age-related Macular Degeneration. Journal of Immunology, 178: 1783 – 1790, 2007

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